Vim li cas thiaj xaiv peb
Peb lub tuam txhab
Lub tuam txhab, nyob hauv Yanhai Industrial Park-Ib ntawm cov tshuaj muaj zog tshaj plaws hauv tuam tsev hauv Suav teb-npog thaj tsam ntawm 35 daim av. Through its three product segments-Guaiacol derivatives, Epichlorohydrin derivatives, and Iodine contrast media-Haizhou Pharm offers a portfolio of products and services globally, including Active Pharmaceutical Ingredients (API), intermediates, fine chemicals, and custom manufacturing services.
GMP Kev Pab Cuam GMP
Nrog cov kws ua haujlwm cog lus ua haujlwm thiab kev cob qhia ntau yam, lub tuam txhab nyob hauv cov chaw lag luam ntev hauv GMP thiab tsis muaj GMP cov xwm txheej.
Ntawv muaj
Haizhou lub cev yog ISO9001 / 14001 thiab OHSAS18001 Pom zoo, thiab ISO / Ohsas Kev Tswjhwm Philosophy Cleats rau tag nrho cov txheej txheem ntawm lub tuam txhab.
Kev Cog Lus Kev Txhim Kho Kev Tshaj Tawm
Nrog cov kws ua haujlwm cog lus ua haujlwm thiab kev cob qhia ntau yam, lub tuam txhab nyob hauv cov chaw lag luam ntev hauv GMP thiab tsis muaj GMP cov xwm txheej.
Yam khoom muaj feem cuam tshuam
API: Rosuvastatin Cocium Cas Tsis muaj: {{{{{}}}}} Kho cov qeb: CadioVardular Tshuaj muaj cov: nyob rau hauv kev txhim kho
API: afatinib CAS TSIS MUAJ: {{{{{{{{}} kho cov qeb: anti-cancer txaus: nyob rau hauv kev txhim kho
API: Enzalutamid Cas Tsis Yog: {{{{{{{{}} kho cov qeb: tiv thaiv kev muaj mob qog noj ntshav: hauv kev txhim kho
API: Pyrazinamide Cas Tsis Yog: {{{{{{}}}}}}}}}}} eciurculosis specification: TPA * Ntawv pov thawj: Los ntawm phiaj los nqis tes
Canagliflozin
API: tauAgliflozin CAS Tsis yog: {{{{{{{{}}} Kho qeb: Ntshav qab zib muaj: nyob rau hauv kev txhim kho
API: Ranolazine Cas Tsis: {{{{{{{{}}} Kho cov qeb: Antianginal Tshuaj Muaj Kev Kho Mob: Nyob rau hauv Kev Tsim Kho
API: Dasatinib Cas Tsis: {{{{{{{{}}} Kho Qeb Qeb: Los tiv thaiv kev muaj mob qog noj ntshav: hauv kev txhim kho
Dasatinib yog dab tsi?
Dasatinib Pharmitynamically BR-ABL Kinase thiab SRC Kinase ua ke nrog rau ob peb lwm cov c-ntsiav, Ephrin Receptor Kinase (Eph), thiab PDFB receptor. Dasatinib yog lub zog, sub-monoparar ntawm BR-ABL Kinase nrog potency nrog}. 8 N}}. 8 N}}. 8 N}}. 8 N}}. 8 N}}. 8 N}}. 8 N}}. 8 N}}. 8 N}}. 8 N}}. 8 N}}. 8 N}}. 8 N}}. 8 N}}. 8 N}}. 8 N}}. 8 N}}. 8 N}}. 8 N}}.
Dasatinib, muaj zog thiab ntau yam tshuaj noj, tau tawm los ua cov neeg ua si tseem ceeb hauv kev kho mob ntawm cov kab mob rwj. Nws tau tsim los ntawm Bristol-Myers Squibb thiab yog feem ntau cov hom phiaj ntawm cov protein tshwj xeeb koom nrog kev loj hlob ntawm cov qog nqaij hlav cancer. Cov tshuaj tau pom zoo rau kev siv hauv cov neeg mob Ib qho ntxiv, nws yog siv rau kev kho Philadelphia chromosome-zoo mob ntsws leukemia (Ph + txhua). Kev tshawb fawb tseem tshawb txog nws txoj kev ua tau zoo rau lwm cov neeg thiab nws cov peev xwm sib xyaw ua ke nrog lwm cov kev kho kom txhim kho cov txiaj ntsig kho tau.
Dasatinib belongs rau chav kawm ntawm cov tshuaj hu ua Tyrosine Kinase Inhibitors (TKIS). Cov neeg inhomitors no lub hom phiaj BCR-ABl-ABl Protein, qhov txawv txav tsis txaus ntseeg nyob rau hauv cov neeg mob cml thiab ph +. Cov enzyme no tau los ntawm caj ces txawv teb chaws hu ua Philadelphia chromosome. Feem ntau, enzymes zoo li bcr-abl ua si lub luag haujlwm hauv kev ua haujlwm cellular xws li kev loj hlob thiab faib. Txawm li cas los xij, hauv cov qog nqaij hlav cancer, BRC-ABL enzyme yog kev ua tsis dhau, ua rau kev tswj hwm lub cev tsis tuaj yeem.
Dasatinib ua haujlwm los ntawm kev thaiv cov kev ua ntawm bCR-ABL thiab lwm yam kev sib tw Tyrosine Kinases, yog li inhibitation ntawm cov kabmob kheesxaws. Los ntawm kev sib tw cov enzymes txawv, Dasatinib yeej tseem ceeb halts qhov kev loj hlob ntawm tus kab mob thiab tuaj yeem ua rau tuag taus hlwb. Qhov kev siv tshuab no tsis yog ua rau Dasatinib tau txais txiaj ntsig zoo rau kev kho mob leukemia tab sis kuj tseem muaj cov kev cuam tshuam, txo qhov kev cuam tshuam rau ib txwm muaj, noj qab haus huv hlwb.
Kev tswj hwm Dasatinib yog qhov ncaj, tab sis nws yuav tsum muaj kev ua raws cov txheej txheem tshwj xeeb kom ntseeg tau tias ua tau zoo thiab txo cov kev mob tshwm sim tsawg dua. Dasatinib muaj nyob rau hauv cov ntaub ntawv ntsiav tshuaj thiab feem ntau yog noj ib zaug txhua hnub, ib tag kis sawv ntxov lossis yav tsaus ntuj. Qhov ntau npaum li cas yuav sib txawv raws li theem ntawm tus kab mob, tus neeg mob lub cev noj qab haus huv tag nrho, thiab lawv ua siab ntev rau cov tshuaj. Nws yog qhov tseem ceeb heev kom ua raws cov tshuaj noj thiab tsis txhob hloov lossis ua kom tsis txhob noj tshuaj yam tsis muaj kev sab laj nrog tus kws kho mob.
Cov ntsiav tshuaj Dasatinib yuav tsum tau nqos tag nrho nrog dej thiab tuaj yeem nqa nrog lossis tsis muaj zaub mov. Txawm li cas los xij, nws yog qhov tseem ceeb kom tsis txhob noj txiv kab ntxwv qaub thiab cov txiv kab ntxwv ua kua txiv ntoo uas lawv tuaj yeem cuam tshuam nrog kev nqus cov ntshav thiab muaj kev pheej hmoo ntawm cov kev mob tshwm sim. Qhov pib ntawm kev nqis tes ua rau Dasatinib tuaj yeem sib txawv. Qee tus neeg mob yuav pib pom kev txhim kho hauv ob peb lub lis piam, thaum rau lwm tus, nws yuav siv sijhawm ntau lub hlis. Kev tshuaj xyuas cov ntshav ib txwm los ntawm kev tshuaj xyuas cov ntshav thiab kuaj pom kev soj ntsuam yog qhov tsim nyog los ntsuas cov tshuaj zoo thiab kho cov tshuaj xyuam yog tias xav tau.
Thaum Dasatinib tau muaj pov thawj los ua kev tshuaj cawm siav rau ntau tus, nws tsis yog tsis muaj nws cov kev mob tshwm sim. Qhov loj heev thiab zaus ntawm cov kev mob tshwm sim tuaj yeem sib txawv ntawm ib tus neeg mus rau lwm tus, nyob ntawm ntau yam kev kho mob, lub sijhawm kho mob, thiab tus neeg mob tag nrho. Cov kev mob tshwm sim muaj xeev siab, raws plab, mob taub hau, qaug zog, thiab mob nqaij. Cov kev mob tshwm sim loj dua tuaj yeem koom nrog cov qe ntshav muaj txiaj ntsig ntau, uas tuaj yeem ua kom muaj kev pheej hmoo kis mob, los ntshav, thiab anemia. Qee tus neeg mob yuav ua tau kom muaj kev tawm dag zog haus dej, uas tuaj yeem tshwm sim pom tias nyob ntawm lub qhov muag, thiab muaj cov kua loj, ua kua hauv lub ntsws lossis lub siab.
Dasatinib muaj cov kev tsis sib haum xeeb. Nws yuav tsum tsis txhob siv rau cov neeg mob uas ua xua rau ib qho ntawm nws cov khoom. Ib qho ntxiv, nws tsis pom zoo rau kev siv thaum lub sijhawm muaj kev pheej hmoo ntawm tus menyuam hauv plab. Cov poj niam ntawm lub hnub nyoog menyuam yaus yuav tsum siv kom muaj kev tiv thaiv kom ua haujlwm thaum noj cov tshuaj Dasatinib thiab rau ib lub sijhawm tom qab tsis siv tshuaj. Kev pub niam mis yog tsis tau qhia thaum kho.
Kev sib cuam tshuam yeeb tshuaj yog qhov kev txiav txim siab tseem ceeb thaum ua thiab noj cov Dasatinib. Qee yam tshuaj noj yuav cuam tshuam li cas cov Dasatinib ua haujlwm lossis nce qhov ntxim nyiam ntawm cov kev mob tshwm sim. Piv txwv, cov tshuaj uas cuam tshuam rau cov cyp3A4, xws li Ketoconazole, tuaj yeem nce qib kom cov ntshav, tuaj yeem ua rau muaj kev pheej hmoo ntawm kev cuam tshuam tsis zoo. Hloov siab, cov tshuaj uas ua rau Cyp3A4, xws li Rifampin, Phenytoin, thiab St. John lub wort, tuaj yeem txo nws txoj kev ua tau zoo.
Other medications that can interact with Dasatinib include antacids and H2 blockers like ranitidine and famotidine, which can reduce the absorption of Dasatinib if taken too closely together. Nws raug nquahu kom noj tshuaj tiv thaiv tsawg kawg yog ob teev ua ntej lossis tom qab Dasatinib. Tsis tas li ntawd, cov tshuaj uas nthuav tawm Qt Interval, yuav tsum tau siv nrog kev ceev faj, nce kev pheej hmoo, nce kev pheej hmoo ntawm cov kev mob plawv kev mob siab.
Ntse ntawm Cov Tshuaj Dasatinib
Ua raws li lub hom phiaj kho, Dasatinib yuav siv rau hauv cov koob tshuaj sib txawv, tshwj xeeb raws li hauv qab no:
Txog kev kho mob ntawm cov neeg mob plab hnyuv rog (CML):
Pib koob tshuaj:100mgx 1 lub sijhawm / yog tias cov lus teb lossis cov lus teb tsis muaj txiaj ntsig tsis tiav, nce qhov koob tshuaj mus rau 140 mg ib zaug txhua hnub. Qhov pom zoo pib koob tshuaj rau flare-ups, meleloid nrawm lossis Lymphoid CML lossis PH + yog 140 mg / hnub. Yog tias hematologic lossis cov lus teb cytological tsis tiav, cov koob tshuaj yuav nce ntxiv rau 180 mg ib zaug txhua hnub.
Txog kev kho mob ntawm cov mob lymphoblastic ntawm cov mob leukemia ph + (txhua yam):
Thawj Koob:140 mg Ib zaug yog hematologic lossis cov lus teb cytological tsis tiav, cov koob tshuaj yuav nce ntxiv rau 180 mg ib zaug txhua hnub. / hnub. Dose hloov kho thaum muaj kuab lom tau tshwm sim: yog hematologic lom neeg tshwm sim, txo cov tshuaj ib ntus, txo cov tshuaj lossis txuas cov tshuaj.
Rau cov menyuam yaus ntawm Ph + CML-CP thiab P + Txhua:
Dasatinib yog muab hais lus ib zaug ib zaug li cov ntsiav tshuaj-coated ntsiav tshuaj. Cov koob tshuaj yuav tsum tau rov ua dua txhua 3 lub hlis raws li kev hloov pauv ntawm lub cev qhov hnyav ntawm tus menyuam. Cov ntsiav tshuaj yuav tsis pom zoo rau cov menyuam yaus uas tsis tau siv rau cov menyuam yaus kom pom zoo rau cov menyuam yaus kom pom zoo rau menyuam yaus tsawg kawg 45 kg: 100 mg / hnub
Kuv yuav tsum noj Dasatinib yuav tsum noj li cas?
Noj Dasatinib raws li cov kws kho mob tau hais los ntawm koj tus kws kho mob. Ua raws li txhua cov lus qhia ntawm koj daim ntawv lo qhia muab tshuaj rau cov tshuaj rau cov lus qhia lossis cov ntawv qhia kev qhia. Koj tus kws kho mob qee zaum koj puas tau hloov koj txoj tshuaj.
Koj yuav noj cov Dasatinib nrog lossis tsis muaj zaub mov. Noj cov tshuaj tib lub sijhawm txhua hnub.
Nqos lub ntsiav tshuaj tag nrho thiab tsis zuaj, zom, lossis zom nws.
Tsis txhob noj ib ntsiav tshuaj uas tau tawg tag. Cov tshuaj los ntawm cov ntsiav tshuaj tsoo lossis tawg tuaj yeem txaus ntshai yog tias nws tau txais hauv koj lub qhov muag, qhov ncauj, lossis ntswg, lossis ntawm koj cov tawv nqaij. Yog tias qhov no tshwm sim, ntxuav koj cov tawv nqaij nrog xab npum thiab dej lossis yaug koj lub qhov muag nrog dej. Hnav hnab looj tes roj hmab thaum tuav ib lub ntsiav tshuaj tawg lossis tshuaj ntsiav. Nug koj tus kws kho mob lossis tus kws muag tshuaj yuav ua li cas kom nyab xeeb muab pov tseg ntawm cov ntsiav tshuaj tawg. Tus poj niam cev xeeb tub yuav tsum tsis txhob muab ib lub ntsiav tshuaj tawg.
Dasatinib tuaj yeem txo cov qe ntshav uas pab koj lub cev tua kab mob thiab pab koj cov ntshav mus rau hauv lub tiaj. Koj cov ntshav yuav tsum raug kuaj ntau zaus. Koj cov kev kho mob cancer yuav raug ncua raws li cov qhabnias ntawm cov kev xeem no.
Proteome Profiling ntawm Tej Peev Xwm Dasatinib ntawm Affinity-Raws Li
Cov Kinases Protein (Pks) Ua lub luag haujlwm tseem ceeb hauv kev txhim kho thiab kev loj hlob ntawm tes, ciaj sia, kev txeeb chaw, thiab Angiogenesis. Dasatinib (BMS -354825}), ib qho dual src / Abl inhibority, yog kev cog lus siv tshuaj tiv thaiv kab ke ntawm qhov ncauj. Nws tau siv rau kev kho mob ntawm imatinib-resistant xeem mineelienous leukemia (cml). Feem ntau Kinase inibitors, suav nrog cov Dasatinib, inhibit ntau lub hom phiaj cellular thiab tsis muaj cov cellular tshwj xeeb.
Cov kev sim siab tsis ntev los no nyob rau hauv Kinase kev tshawb fawb yog li tsom rau kev loj hlob ntawm cov txheej txheem ntawm lub peev xwm ntawm lub peev xwm (on thiab tawm ntawm Kiners inibitors. Feem ntau cov txheej txheem uas twb muaj lawm, txawm li cas los xij, tseem muaj teeb meem tseem muaj teeb meem thiab feem ntau tsis tau tshaj nrog cov kev tshawb fawb nyob hauv lub neej. Nyob rau hauv txoj haujlwm no, peb tau ua tiav cov kev sojntsuam ntawm tes ntawm lub xov tooj (da {}}}}}}}}
Nyob rau hauv txoj kev no, siab tswj hwm, Comparteralized Kinase-Tshuaj sib cuam tshuam tau raug tswj xyuas. Los ntawm kev sib piv cov txiaj ntsig tau los ntawm kev sib txawv cov teeb meem sib txawv (nyob hauv lub cev Ntxiv rau ABL thiab SRC tsev neeg Tyrosine Kinases Dasatinib lub hom phiaj tau raug txheeb xyuas, suav nrog ob peb lub serine / Thnc)} A, PE}, PKA C-, thiab PNK2).
Lawv tau txuas ntxiv los ntawm kev rub tawm los ntawm kev rub tawm / txhaj tshuaj tiv thaiv kab mob nrog rau Kinase Inhibition kev cia siab. Cov kev tshawb fawb ntxiv yog qhov xav tau kom nkag siab zoo dua ntawm Dasatinib thiab nws cov peev xwm ntawm cov twj tshuaj uas tau txheeb xyuas ntawm cov ntsiab lus ntawm lub ntsej muag tshiab. Cov hau kev tsim ntawm no yuav tsum tau txais txiaj ntsig zoo rau kev kawm ntawm ntau cov kev hloov tshuaj / cov yeeb ncuab uas twb muaj lawm.
Kho rau Dasatinib
Dasatinib yog dual abl / src tyrosine Kinase inhibitor (Nilotinib, thiab ponatinib, thiab ponatinib, thiab ponatinib, thiab ponatinib, thiab ponatinib, thiab ponatinib, thiab ponatinib, thiab ponatinib, thiab ponatinib, thiab ponatinib, thiab ponatinib, thiab ponatinib thiab tau pom tias muaj peev xwm immunomodulatory. Dasatinib tau pom zoo rau kev kho ntawm txhua ntu ntawm cov kab mob qog nqaij hlav mekemia (cml) thiab kev kho mob ua ntej rau cml rau CML hauv Pass.
Peb Lub Hoobkas
Lub tuam txhab, nyob hauv Yanhai Industrial Park, ib qho ntawm cov tshuaj muaj ntau tshaj plaws hauv paus hauv Suav teb, npog thaj tsam ntawm 35 ev kawj. Los ntawm nws peb cov khoom lag luam - Gualiolen derivatives, epichlorohdrin derivical cov khoom lag luam (API
Cov FAQ
Cim npe nrov: Dasatinib, Tuam Tshoj Dasatinib Cov Chaw Tsim Tshuaj, Chaw muag khoom, Hoobkas
